Dr Maja Simić - Plastična hirurgija 1
Dr Maja Simić - Plastična hirurgija 2
Dr Maja Simić - Plastična hirurgija 3
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Collagen Stimulators — Skin Regeneration from Within

Modern aesthetics increasingly strives for natural results.
Rather than immediate filling, the goal is to restore skin structure and stimulate its own potential.

Collagen stimulators represent treatments that not only restore volume, but activate regeneration processes and improve skin quality in the long term.


What are collagen stimulators?

Collagen is the key protein responsible for firmness, elasticity and a youthful appearance of the skin.
With age, its levels naturally decrease, leading to loss of tone and the appearance of wrinkles.

Unlike conventional fillers that act immediately, collagen stimulators gradually stimulate fibroblasts to produce natural collagen again, making the skin tighter, denser and smoother.

In the practice of Dr Maja Simić, two modern collagen stimulators are most commonly used:

  • Aesplla — a biocompatible polylactic acid stimulator that promotes formation of new collagen and restores skin structure from within.
    The effect develops gradually over several weeks and lasts up to two years.

  • HarmonyCa — an innovative hybrid filler that combines calcium hydroxylapatite (stimulates collagen) and hyaluronic acid (immediately restores volume and hydration).
    This combination provides immediately visible and long-lasting natural rejuvenation effect.


Who is the ideal candidate?

Collagen stimulators are intended for individuals who wish to achieve:

  • Natural rejuvenation without abrupt changes
  • Improvement of skin tone, texture and elasticity
  • Softening of laxity in the lower third of the face and cheek region
  • Long-lasting effect while preserving natural facial movement and proportions

What does the treatment involve?

Following detailed facial analysis, the type of stimulator and area of application are determined.
The product is applied with a thin cannula or needle into the deeper layers of the skin, initiating the process of neocollagenesis — formation of new collagen.

The treatment takes approximately 30 minutes and does not require a recovery period.
After application, brief massage of the treated area is recommended for several days, to ensure even distribution of the product.


Results and duration of effect

The effect is not immediate — it builds gradually over several weeks, as the skin begins to produce collagen itself.
Results are long-lasting, for 12 to 24 months, and skin quality continues to improve even after the product itself is resorbed.

The skin becomes firmer, more elastic and more radiant, with a natural, rested appearance.


Why choose collagen stimulators?

Because they offer natural rejuvenation from within — without changing facial features and without excess volume.
The goal is not immediate transformation, but long-term skin regeneration and restoration of its youthful structure.


💬 Philosophy of treatment:
"The most beautiful results are those that the skin itself creates with the right support."